Multiple studies surrounding the existing use of paper patient information leaflets (PILs) and the implementation of electronic PILs (ePILs) for medicines have been conducted globally. Furthermore, several countries have already successfully implemented electronic product information (ePI), with many others, including the UK, currently initiating discussions to do so. This evidence review collates the existing data with a focus on how patients and healthcare professionals (HCPs) currently access PILs and healthcare information, and the challenge and opportunities of the transition from paper PILs to ePILs in the UK. It will also inform the prioritisation and design of any proof-of-concept and pilot studies to be considered by the UK ePI Task Force, while ensuring that patients are at the heart of any solution. The diversity and inclusion of those who may be unable to access digital information are considered as part of this review so that appropriate mechanisms can be developed to ensure that no patient is left behind. The findings show a clear growing interest for both patients and HCPs in seeking health information online and a digital readiness within the UK population to do so. As a result, this review provides the evidence to support the introduction of ePILs, without accompanying paper leaflets, for hospital-use medicines (medicines administered in the presence of an HCP in a hospital environment) in the UK without the need for further studies, while ensuring that the PIL is always accessible in some format to anyone who needs it. Further studies are proposed for prescription medicines and those available ‘over the counter’ (available in pharmacies or general sales list) prior to consideration for ePIL implementation and the transition away from paper PILs.